01 - Whisk together buttermilk, salt, black pepper, garlic powder, and paprika in a large bowl. Add chicken breasts and turn to coat. Cover and refrigerate for at least 30 minutes, or up to 4 hours for tenderness.
02 - In a shallow dish, combine flour, panko, paprika, cayenne pepper, oregano, salt, and black pepper thoroughly.
03 - Remove chicken from marinade, allowing excess to drip off. Dredge each breast in the flour mixture, pressing lightly to adhere the coating evenly.
04 - Warm vegetable oil in a large nonstick or cast-iron skillet over medium-high heat until shimmering.
05 - Place chicken breasts in hot oil and cook for 5 to 6 minutes per side until golden brown and internal temperature reaches 165°F. Adjust heat to prevent burning.
06 - Transfer cooked chicken to a plate lined with paper towels to absorb excess oil. Let rest for 5 minutes before serving.