01 - Preheat oven to 350°F. Grease a 9x13-inch baking dish with cooking spray or butter.
02 - Cut refrigerated biscuit dough into 1-inch pieces. Scatter pieces evenly in the prepared baking dish.
03 - In a medium bowl, combine biscuit pieces with 1 cup pizza sauce and half the mozzarella cheese. Toss until evenly coated.
04 - Spread coated biscuit pieces evenly across the bottom of the dish. Pour remaining pizza sauce over the top.
05 - Layer pepperoni, black olives, and bell peppers over the biscuit base.
06 - Sprinkle remaining mozzarella and cheddar cheese evenly over the toppings.
07 - Distribute Italian herbs, garlic powder, crushed red pepper flakes (if using), salt, and black pepper evenly over the top.
08 - Bake uncovered for 30-35 minutes until biscuits are puffed and golden brown, and cheese is bubbly.
09 - Let casserole rest for 5 minutes before serving to allow cheese to set slightly.